Targeting GABAB receptors for anti-abuse drug discovery.

@article{Phillips2014TargetingGR,
  title={Targeting GABAB receptors for anti-abuse drug discovery.},
  author={Tamara J Phillips and Cheryl J. Reed},
  journal={Expert opinion on drug discovery},
  year={2014},
  volume={9 11},
  pages={
          1307-17
        }
}
INTRODUCTION There is increasing evidence encouraging the development of drugs that positively modulate the γ-aminobutyric acid type B (GABA(B)) receptor for combating addiction. Compounds that target GABA(B) receptors are unique as anti-abuse therapies because of their impact against multiple addictive drugs. AREAS COVERED The authors present the basic information concerning the drug actions of GABA and GABA(B) receptor orthosteric agonists and positive allosteric modulators (PAM… CONTINUE READING
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