Targeting Free Radicals in Oxidative Stress-Related Human Diseases.

@article{Poprac2017TargetingFR,
  title={Targeting Free Radicals in Oxidative Stress-Related Human Diseases.},
  author={Patrik Poprac and K. Jomov{\'a} and Miriama {\vS}imunkov{\'a} and V. Koll{\'a}r and C. Rhodes and M. Valko},
  journal={Trends in pharmacological sciences},
  year={2017},
  volume={38 7},
  pages={
          592-607
        }
}
Cancer and Alzheimer's disease (AD) are characterized by (i) opposing biological mechanisms, (ii) an inverse correlation between their incidences, and (iii) oxidative stress being a common denominator of both diseases. Increased formation of reactive oxygen species (ROS) in cancer cells from oncogenic signaling and/or metabolic disturbances leads to upregulation of cellular antioxidant capacity to maintain ROS levels below a toxic threshold. Combining drugs that induce high levels of ROS with… Expand
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