Targeting Focal Adhesion Kinase Suppresses the Malignant Phenotype in Rhabdomyosarcoma Cells1

@inproceedings{Waters2016TargetingFA,
  title={Targeting Focal Adhesion Kinase Suppresses the Malignant Phenotype in Rhabdomyosarcoma Cells1},
  author={Alicia M. Waters and Laura L Stafman and Evan F. Garner and Smitha Mruthyunjayappa and Jerry E. Stewart and Elizabeth C Mroczek-Musulman and Elizabeth A Beierle},
  booktitle={Translational oncology},
  year={2016}
}
Despite the tremendous advances in the treatment of childhood solid tumors, rhabdomyosarcoma (RMS) continues to provide a therapeutic challenge. Children with metastatic or relapsed disease have a disease-free survival rate under 30%. Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase that is important in many facets of tumorigenesis. Signaling pathways both upstream and downstream to FAK have been found to be important in sarcoma tumorigenesis, leading us to hypothesize that FAK… CONTINUE READING

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