Targeting FcRn for the modulation of antibody dynamics.


The MHC class I-related receptor, FcRn, is a multitasking protein that transports its IgG ligand within and across cells of diverse origins. The role of this receptor as a global regulator of IgG homeostasis and transport, combined with knowledge of the molecular details of FcRn-IgG interactions, has led to opportunities to modulate the in vivo dynamics of… (More)
DOI: 10.1016/j.molimm.2015.02.007


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