Targeting Fatty Acid Binding Protein (FABP) Anandamide Transporters – A Novel Strategy for Development of Anti-Inflammatory and Anti-Nociceptive Drugs

@inproceedings{Berger2012TargetingFA,
  title={Targeting Fatty Acid Binding Protein (FABP) Anandamide Transporters – A Novel Strategy for Development of Anti-Inflammatory and Anti-Nociceptive Drugs},
  author={William T. Berger and Brian P. Ralph and Martin Kaczocha and Jing Sun and Trent E. Balius and Robert C. Rizzo and Samir Haj-Dahmane and Iwao Ojima and Dale G. Deutsch},
  booktitle={PloS one},
  year={2012}
}
Fatty acid binding proteins (FABPs), in particular FABP5 and FABP7, have recently been identified by us as intracellular transporters for the endocannabinoid anandamide (AEA). Furthermore, animal studies by others have shown that elevated levels of endocannabinoids resulted in beneficial pharmacological effects on stress, pain and inflammation and also ameliorate the effects of drug withdrawal. Based on these observations, we hypothesized that FABP5 and FABP7 would provide excellent… CONTINUE READING

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