Targeting Fatty-Acid Amide Hydrolase with Prodrugs for CNS-Selective Therapy.

@article{Meinig2017TargetingFA,
  title={Targeting Fatty-Acid Amide Hydrolase with Prodrugs for CNS-Selective Therapy.},
  author={J Matthew Meinig and Skylar J Ferrara and Tania Banerji and Tapasree Banerji and Hannah S Sanford-Crane and Dennis N. Bourdette and Thomas S. Scanlan},
  journal={ACS chemical neuroscience},
  year={2017},
  volume={8 11},
  pages={
          2468-2476
        }
}
The blood-brain barrier (BBB) can be a substantial impediment to achieving therapeutic levels of drugs in the CNS. Certain chemical functionality such as the carboxylic acid is a general liability for BBB permeability preventing significant CNS distribution of a drug from a systemic dose. Here, we report a strategy for CNS-selective distribution of the carboxylic acid containing thyromimetic sobetirome using prodrugs targeted to fatty-acid amide hydrolase (FAAH), which is expressed in the brain… CONTINUE READING

Citations

Publications citing this paper.

Myelin repair stimulated by CNS-selective thyroid hormone action.

VIEW 6 EXCERPTS
CITES METHODS, RESULTS & BACKGROUND