Targeting FOXM1 in cancer.

@article{Halasi2013TargetingFI,
  title={Targeting FOXM1 in cancer.},
  author={Marianna Halasi and Andrei L. Gartel},
  journal={Biochemical pharmacology},
  year={2013},
  volume={85 5},
  pages={644-52}
}
Oncogenic transcription factor FOXM1 is overexpressed in the majority of human cancers. In addition, FOXM1 has been implicated in cell migration, invasion, angiogenesis and metastasis. The important role of FOXM1 in cancer affirms its significance for therapeutic intervention. Current data suggest that targeting FOXM1 in mono- or combination therapy may have promising therapeutic benefits for the treatment of cancer. However, challenges with the delivery of anti-FOXM1 siRNA to tumors and the… CONTINUE READING

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