Targeting Efficiency of Galactosylated Liposomes to Hepatocytes in Vivo: Effect of Lipid Composition

@article{Murao2002TargetingEO,
  title={Targeting Efficiency of Galactosylated Liposomes to Hepatocytes in Vivo: Effect of Lipid Composition},
  author={Aki Murao and Makiya Nishikawa and Chittima Managit and Joseph Wong and Shigeru Kawakami and Fumiyoshi Yamashita and Mitsuru Hashida},
  journal={Pharmaceutical Research},
  year={2002},
  volume={19},
  pages={1808-1814}
}
AbstractPurpose. To investigate the effects of the lipid composition of galactosylated liposomes on their targeted delivery to hepatocytes. Methods. Several types of liposomes with a particle size of about 90 nm were prepared using distearoyl-L-phosphatidylcholine (DSPC), cholesterol (Chol) and cholesten-5-yloxy-N-(4-((1-imino-2-D-thiogalactosylethyl)amino)butyl)formamide (Gal-C4-Chol), and labeled with [3H]cholesterol hexadecyl ether. Their tissue disposition was investigated in mice following… CONTINUE READING

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