Targeting ERBB receptors shifts their partners and triggers persistent ERK signaling through a novel ERBB/EFNB1 complex.

@article{Vermeer2013TargetingER,
  title={Targeting ERBB receptors shifts their partners and triggers persistent ERK signaling through a novel ERBB/EFNB1 complex.},
  author={Paola D Vermeer and Paul L Colbert and Bryant G. Wieking and Daniel W Vermeer and John Hyung Lee},
  journal={Cancer research},
  year={2013},
  volume={73 18},
  pages={
          5787-97
        }
}
Most squamous cell carcinomas of the head and neck (HNSCC) overexpress ERBB1/EGFR, but EGF receptor (EGFR)-targeted therapies have yielded disappointing clinical results in treatment of this cancer. Here, we describe a novel interaction between EGFR and the ligand EphrinB1 (EFNB1), and we show that EFNB1 phosphorylation and downstream signaling persists in the presence of cetuximab. Mechanistically, cetuximab drives a shift in EGFR dimerization partners within the signaling complex, suggesting… CONTINUE READING
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