Targeting Dyrk1A with AAVshRNA attenuates motor alterations in TgDyrk1A, a mouse model of Down syndrome.

Abstract

Genetic-dissection studies carried out with Down syndrome (DS) murine models point to the critical contribution of Dyrk1A overexpression to the motor abnormalities and cognitive deficits displayed in DS individuals. In the present study we have used a murine model overexpressing Dyrk1A (TgDyrk1A mice) to evaluate whether functional CNS defects could be… (More)
DOI: 10.1016/j.ajhg.2008.09.010

Topics

Cite this paper

@article{OrtizAbalia2008TargetingDW, title={Targeting Dyrk1A with AAVshRNA attenuates motor alterations in TgDyrk1A, a mouse model of Down syndrome.}, author={Jon Ortiz-Abalia and Ignasi Sah{\'u}n and Xavier Altafaj and N{\'u}ria Andreu and Xavier Estivill and Mara Dierssen and Cristina Fillat}, journal={American journal of human genetics}, year={2008}, volume={83 4}, pages={479-88} }