Targeting DNA-PKcs and ATM with miR-101 Sensitizes Tumors to Radiation

@inproceedings{Yan2010TargetingDA,
  title={Targeting DNA-PKcs and ATM with miR-101 Sensitizes Tumors to Radiation},
  author={Dan Yan and Wooi Loon Ng and Xiangming Zhang and Ping Wang and Zhaobin Zhang and Yin-yuan Mo and Hui Mao and Chunhai Hao and Jeffrey L Olson and Walter J. Curran and Ya Wang},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Radiotherapy kills tumor-cells by inducing DNA double strand breaks (DSBs). However, the efficient repair of tumors frequently prevents successful treatment. Therefore, identifying new practical sensitizers is an essential step towards successful radiotherapy. In this study, we tested the new hypothesis: identifying the miRNAs to target DNA DSB repair genes could be a new way for sensitizing tumors to ionizing radiation. PRINCIPAL FINDINGS HERE, WE CHOSE TWO GENES: DNA-PKcs (an… CONTINUE READING

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