Targeting DAX-1 in embryonic stem cells and cancer.

  title={Targeting DAX-1 in embryonic stem cells and cancer.},
  author={Enzo Lalli and Javier Alonso},
  journal={Expert opinion on therapeutic targets},
  volume={14 2},
IMPORTANCE OF THE FIELD DAX-1 (NR0B1) is an unusual orphan nuclear receptor whose function is essential for the development of the human adrenal cortex and onset of puberty. Recent data have implicated this transcription factor also in embryonic stem cell and cancer biology. AREAS COVERED IN THIS REVIEW The role of DAX-1 in the regulation of development and function of the adrenal cortex, reproductive axis, embryonic stem cells and a few types of cancer. WHAT THE READER WILL GAIN Here we… CONTINUE READING

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