Targeting Cyclic Nucleotide Phosphodiesterase in the Heart: Therapeutic Implications

@article{Miller2010TargetingCN,
  title={Targeting Cyclic Nucleotide Phosphodiesterase in the Heart: Therapeutic Implications},
  author={Clint L. Miller and Chen Yan},
  journal={Journal of Cardiovascular Translational Research},
  year={2010},
  volume={3},
  pages={507-515}
}
The second messengers, cAMP and cGMP, regulate a number of physiological processes in the myocardium, from acute contraction/relaxation to chronic gene expression and cardiac structural remodeling. Emerging evidence suggests that multiple spatiotemporally distinct pools of cyclic nucleotides can discriminate specific cellular functions from a given cyclic nucleotide-mediated signal. Cyclic nucleotide phosphodiesterases (PDEs), by hydrolyzing intracellular cyclic AMP and/or cyclic GMP, control… CONTINUE READING

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