Targeting Class A and C Serine β-Lactamases with a Broad-Spectrum Boronic Acid Derivative

@article{Tondi2014TargetingCA,
  title={Targeting Class A and C Serine β-Lactamases with a Broad-Spectrum Boronic Acid Derivative},
  author={D. Tondi and A. Venturelli and R. Bonnet and C. Pozzi and B. Shoichet and Maria Paola Costi},
  journal={Journal of Medicinal Chemistry},
  year={2014},
  volume={57},
  pages={5449 - 5458}
}
Production of β-lactamases (BLs) is the most widespread resistance mechanism adopted by bacteria to fight β-lactam antibiotics. The substrate spectrum of BLs has become increasingly broad, posing a serious health problem. Thus, there is an urgent need for novel BL inhibitors. Boronic acid transition-state analogues are able to reverse the resistance conferred by class A and C BLs. We describe a boronic acid analogue possessing interesting and potent broad-spectrum activity vs class A and C… Expand
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