Targeting COPD: advances on low-molecular-weight inhibitors of human neutrophil elastase.

@article{Lucas2013TargetingCA,
  title={Targeting COPD: advances on low-molecular-weight inhibitors of human neutrophil elastase.},
  author={Susana D Lucas and Elsa Costa and Rita C. Guedes and Rui Moreira},
  journal={Medicinal research reviews},
  year={2013},
  volume={33 Suppl 1},
  pages={E73-101}
}
Chronic obstructive pulmonary disease (COPD) is a major increasing health problem and the World Health Organization (WHO) reports COPD as the fifth leading cause of death worldwide. COPD refers to a condition of inflammation and progressive weakening of the structure of the lung as well as irreversible narrowing of the airways. Current treatment is only palliative and no available drug halts the progression of the disease. Human neutrophil elastase (HNE) is a serine protease, which plays a… CONTINUE READING
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