Targeting CGRP via receptor antagonism and antibody neutralisation in two distinct rodent models of migraine-like pain

@article{Christensen2019TargetingCV,
  title={Targeting CGRP via receptor antagonism and antibody neutralisation in two distinct rodent models of migraine-like pain},
  author={Sarah L T Christensen and Steffen E. Petersen and David M{\o}bjerg Kristensen and Jes Olesen and Gordon R. Munro},
  journal={Cephalalgia},
  year={2019},
  volume={39},
  pages={1827 - 1837}
}
Introduction Rodent disease models can play an indispensable role in drug development. Confirming that translationally-relevant disease mechanisms are engaged in such models is a crucial facet of this process. Accordingly, we have validated the role of calcitonin gene-related peptide signaling in a mouse model of glyceryl trinitrate-provoked migraine-like pain and a spontaneous rat model of migraine-like pain by assessing their pharmacological responsiveness to the small molecule calcitonin… CONTINUE READING