Targeting CD22 in B-cell Malignancies: Current Status and Clinical Outlook

  title={Targeting CD22 in B-cell Malignancies: Current Status and Clinical Outlook},
  author={Loretta Sullivan-Chang and Robert T. O’Donnell and Joseph M Tuscano},
CD22 is a B-cell-specific transmembrane glycoprotein found on the surface of most B cells; it modulates B-cell function, survival and apoptosis. CD22 has emerged as an ideal target for monoclonal antibody (mAb)-based therapy of B-cell malignancies including most lymphomas and many leukemias. Epratuzumab, an anti-CD22 mAb, has been developed in various forms, including as an unlabeled (naked) mAb, as a radioimmunotherapeutic, as an antibody drug conjugate (ADC), and as a vehicle for CD22… CONTINUE READING
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