Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation.

@article{Sukhanova2013TargetingCG,
  title={Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation.},
  author={Anna Sukhanova and Andrey Gorin and Ilya G. Serebriiskii and Linara Gabitova and Hui Zheng and Diana Restifo and Brian L. Egleston and Deborah H. Cunningham and Tetyana V. Bagnyukova and Hanqing Liu and Anna N. Nikonova and Gregory P. Adams and Yan Zhou and Dong-hua Yang and Ranee Mehra and Barbara A Burtness and Kathy Qi Cai and Andres J. P. Klein-Szanto and Lisa E. Kratz and Richard I Kelley and Louis M. Weiner and GailE. Herman and Erica A Golemis and Igor Astsaturov},
  journal={Cancer discovery},
  year={2013},
  volume={3 1},
  pages={
          96-111
        }
}
UNLABELLED Persistent signaling by the oncogenic EGF receptor (EGFR) is a major source of cancer resistance to EGFR targeting. We established that inactivation of 2 sterol biosynthesis pathway genes, SC4MOL (sterol C4-methyl oxidase-like) and its partner, NSDHL (NADP-dependent steroid dehydrogenase-like), sensitized tumor cells to EGFR inhibitors. Bioinformatics modeling of interactions for the sterol pathway genes in eukaryotes allowed us to hypothesize and then extensively validate an… CONTINUE READING

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