Targeting C-reactive protein for the treatment of cardiovascular disease

@article{Pepys2006TargetingCP,
  title={Targeting C-reactive protein for the treatment of cardiovascular disease},
  author={M. Pepys and G. M. Hirschfield and G. Tennent and J. R. Gallimore and M. Kahan and V. Bellotti and P. Hawkins and R. Myers and M. D. Smith and A. Polara and Alexander J. A. Cobb and Steven V. Ley and J. Aquilina and C. Robinson and I. Sharif and G. Gray and C. Sabin and Michelle C. Jenvey and S. Kolstoe and D. Thompson and S. P. Wood},
  journal={Nature},
  year={2006},
  volume={440},
  pages={1217-1221}
}
  • M. Pepys, G. M. Hirschfield, +18 authors S. P. Wood
  • Published 2006
  • Medicine
  • Nature
  • Complement-mediated inflammation exacerbates the tissue injury of ischaemic necrosis in heart attacks and strokes, the most common causes of death in developed countries. Large infarct size increases immediate morbidity and mortality and, in survivors of the acute event, larger non-functional scars adversely affect long-term prognosis. There is thus an important unmet medical need for new cardioprotective and neuroprotective treatments. We have previously shown that human C-reactive protein… CONTINUE READING
    Role of C-Reactive Protein at Sites of Inflammation and Infection
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