Targeting Bax interaction sites reveals that only homo-oligomerization sites are essential for its activation

@article{Peng2013TargetingBI,
  title={Targeting Bax interaction sites reveals that only homo-oligomerization sites are essential for its activation},
  author={Rui Peng and J-S Tong and Hong-yuan Li and Bin Yue and Fei Zou and Jiang Yu and Liuping Zhang},
  journal={Cell Death and Differentiation},
  year={2013},
  volume={20},
  pages={744-754}
}
Bax is a proapoptotic Bcl-2 family member that has a central role in the initiation of mitochondria-dependent apoptosis. However, the mechanism of Bax activation during apoptosis remains unsettled. It is believed that the activation of Bax is mediated by either dissociation from prosurvival Bcl-2 family members, or direct association with BH3-only members. Several interaction sites on Bax that mediate its interactions with other Bcl-2 family members, as well as its proapoptotic activity, have… CONTINUE READING
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