Targeting BAFF: immunomodulation for autoimmune diseases and lymphomas.

  title={Targeting BAFF: immunomodulation for autoimmune diseases and lymphomas.},
  author={Andrew P. R. Sutherland and Fabienne Mackay and Charles R Mackay},
  journal={Pharmacology & therapeutics},
  volume={112 3},
In an effort to develop more effective treatments for inflammatory diseases, immunologists have targeted numerous molecular pathways, but with limited success. Notable exceptions are anti-TNF agents, which have proved efficacious in a proportion of rheumatoid arthritis (RA) patients. Another TNF family member, termed BAFF ("B cell-activating factor belonging to the TNF family"), plays a central role in autoimmune diseases, as well as in B cell maturation, survival, and T cell activation. Agents… CONTINUE READING


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