Targeting B7‐1 in immunotherapy

  title={Targeting B7‐1 in immunotherapy},
  author={Rui Chen and Aravindhan Ganesan and Isobel S Okoye and Elena Arutyunova and Shokrollah Elahi and M. Joanne Lemieux and Khaled H. Barakat},
  journal={Medicinal Research Reviews},
  pages={654 - 682}
Modulation of T‐cell immune functions by blocking key immune checkpoint protein interactions using monoclonal antibodies (mAbs) has been an innovative immunotherapeutic strategy. T‐cells are regulated by different checkpoint proteins at the immunological synapse including the B7 ligands (B7‐1 or CD80 and B7‐2 or CD86), which is discussed in this review. These ligands are typically expressed on antigen presenting cells and interact with CD28 and cytotoxic T lymphocyte antigen‐4 (CTLA‐4… 
New insights into checkpoint inhibitor immunotherapy and its combined therapies in hepatocellular carcinoma: from mechanisms to clinical trials
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Understanding the CD28/CTLA‐4 (CD152) Pathway and Its Implications for Costimulatory Blockade
  • D. Gardner, L. Jeffery, D. Sansom
  • Biology
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2014
An updated view of CTLA‐4 biology is provided, reviewing the established features of the system and highlighting its interplay with CD28, and how recent progress in understanding of this pathway affects the authors' interpretations following intervention is discussed.
The blockade of immune checkpoints in cancer immunotherapy
  • D. Pardoll
  • Biology, Medicine
    Nature Reviews Cancer
  • 2012
Preliminary clinical findings with blockers of additional immune-checkpoint proteins, such as programmed cell death protein 1 (PD1), indicate broad and diverse opportunities to enhance antitumour immunity with the potential to produce durable clinical responses.
The role of B7 costimulation in T‐cell immunity
The present review outlines the current understanding of the physiological role of B7 costimulatory signals in regulating CD4+ T cell responses and identifies two major signalling pathways responsible for delivery.
At the Bench: Preclinical rationale for CTLA‐4 and PD‐1 blockade as cancer immunotherapy
The unique mechanisms and sites of action of CTLA‐4 and PD‐1 suggest that although blockade of either has the potential to promote anti‐tumor immune responses, combined blockade of both might offer even more potent anti‐Tumor activity.
A more selective costimulatory blockade of the CD28‐B7 pathway
The current understanding of this complex costimulatory pathway involving co‐stimulatory and co‐inhibitory molecules and the way the authors can manipulate these molecules to inhibit, stimulate or kill target cells is summarized in experimental preclinical models as well as in clinical trials.
Coinhibitory Receptor Expression and Immune Checkpoint Blockade: Maintaining a Balance in CD8+ T Cell Responses to Chronic Viral Infections and Cancer
Recent advances are reviewed that provide a clearer insight into the role of coinhibitory receptor expression in T cell exhaustion and reveal novel antibody-blockade therapeutic targets for chronic viral infections and cancer.
Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies
It is concluded that the combination of direct enhancement of Teff cell function and concomitant inhibition of T reg cell activity through blockade of CTLA-4 on both cell types is essential for mediating the full therapeutic effects of anti–CTLA- 4 antibodies during cancer immunotherapy.
Cancer immunotherapy by targeting immune checkpoints: mechanism of T cell dysfunction in cancer immunity and new therapeutic targets
  • H. Tsai, P. Hsu
  • Biology, Medicine
    Journal of Biomedical Science
  • 2017
Recent advance(s) in molecular understanding of T cell dysfunction in tumor microenvironments are reviewed and new immune checkpoint targets in cancer therapy are discussed.
Paradoxical inhibition of T-cell function in response to CTLA-4 blockade; heterogeneity within the human T-cell population
It is demonstrated here that CTLA-4 blockade can enhance or inhibit the clonal expansion of different T cells that respond to the same antigen, depending on both the T-cell activation state and the strength of theT-cell receptor signal delivered during T- cell stimulation.