Targeting B cells in atherosclerosis: closing the gap from bench to bedside.

@article{Tsiantoulas2015TargetingBC,
  title={Targeting B cells in atherosclerosis: closing the gap from bench to bedside.},
  author={Dimitrios Tsiantoulas and Andrew P. Sage and Ziad Mallat and Christoph J. Binder},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2015},
  volume={35 2},
  pages={296-302}
}
Atherosclerotic plaque formation is strongly influenced by different arms of the immune system, including B lymphocytes. B cells are divided into 2 main families: the B1 and the B2 cells. B1 cells are atheroprotective mainly via the production of natural IgM antibodies that bind oxidized low-density lipoprotein and apoptotic cells. B2 cells, which include… CONTINUE READING