Targeting ATR/CHK1 pathway in acute myeloid leukemia to overcome chemoresistance.

@article{David2017TargetingAP,
  title={Targeting ATR/CHK1 pathway in acute myeloid leukemia to overcome chemoresistance.},
  author={Laure David and St{\'e}phane Manenti and Christian R{\'e}cher and J S Hoffmann and Christine Didier},
  journal={Molecular & cellular oncology},
  year={2017},
  volume={4 5},
  pages={e1289293}
}
Resistance of acute myeloid leukemia to current therapies leads to frequent relapses. Identification of molecular mechanisms involved in chemoresistance constitutes a key challenge to define new therapeutic concepts. Here, we show that the ATR/CHK1 pathway, essential in maintaining genomic stability, is involved in resistance and proliferation characteristics of leukemic cells.