Targeting ASCT2‐mediated glutamine uptake blocks prostate cancer growth and tumour development

  title={Targeting ASCT2‐mediated glutamine uptake blocks prostate cancer growth and tumour development},
  author={Qian Wang and Rae‐Anne Hardie and Andrew J Hoy and Michelle van Geldermalsen and Dadi Gao and Ladan Fazli and Martin C Sadowski and Seher Balaban and Mark Schreuder and R. Nagarajah and Justin S. J. Wong and Cynthia Metierre and Natalia Pinello and Nicholas James Otte and Melanie L. Lehman and Martin G Gleave and Colleen C. Nelson and Charles G. Bailey and William Ritchie and John E J Rasko and Jeff Holst},
  booktitle={The Journal of pathology},
Glutamine is conditionally essential in cancer cells, being utilized as a carbon and nitrogen source for macromolecule production, as well as for anaplerotic reactions fuelling the tricarboxylic acid (TCA) cycle. In this study, we demonstrated that the glutamine transporter ASCT2 (SLC1A5) is highly expressed in prostate cancer patient samples. Using LNCaP and PC-3 prostate cancer cell lines, we showed that chemical or shRNA-mediated inhibition of ASCT2 function in vitro decreases glutamine… CONTINUE READING
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