Targeting ALT: the role of alternative lengthening of telomeres in pathogenesis and prevention of cancer.

@article{Bollmann2007TargetingAT,
  title={Targeting ALT: the role of alternative lengthening of telomeres in pathogenesis and prevention of cancer.},
  author={F Mathias Bollmann},
  journal={Cancer treatment reviews},
  year={2007},
  volume={33 8},
  pages={
          704-9
        }
}
Telomere shortening in the course of cell divisions plays an important role in both suppression and pathogenesis of cancer. Telomere maintenance mechanisms such as telomerase and alternative lengthening of telomeres (ALT) are essential for long-term tumor growth. Consequently, interdiction of telomere lengthening has been proposed as an anti-cancer treatment but requires insight in the genes and pathways involved. In this article, the molecular and functional details of ALT are reviewed, and… CONTINUE READING
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