Targeted viral delivery of Cre recombinase induces conditional gene deletion in cardiovascular circuits of the mouse brain.

@article{Sinnayah2004TargetedVD,
  title={Targeted viral delivery of Cre recombinase induces conditional gene deletion in cardiovascular circuits of the mouse brain.},
  author={Puspha Sinnayah and Timothy E. Lindley and Patrick D. Staber and Beverly L. Davidson and Martin D. Cassell and Robin L. Davisson},
  journal={Physiological genomics},
  year={2004},
  volume={18 1},
  pages={25-32}
}
The Cre/loxP system has shown promise for investigating genes involved in nervous system function and pathology, although its application for studying central neural regulation of cardiovascular function and disease has not been explored. Here, we report for the first time that recombination of loxP-flanked genes can be achieved in discrete cardiovascular regulatory nuclei of adult mouse brain using targeted delivery of adenovirus (Ad) or feline immunodeficiency virus (FIV) bearing Cre… CONTINUE READING