Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cells.

@article{Doan2004TargetedTR,
  title={Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cells.},
  author={Loretta L. Doan and Susan D. Porter and Zhijun Duan and Marcella M. Flubacher and Diego Montoya and Philip N Tsichlis and Marshall Horwitz and Cyril Blake Gilks and H. Leighton Grimes},
  journal={Nucleic acids research},
  year={2004},
  volume={32 8},
  pages={2508-19}
}
Growth factor independence-1 (GFI1) and GFI1B are closely related, yet differentially expressed transcriptional repressors with nearly identical DNA binding domains. GFI1 is upregulated in the earliest thymocyte precursors, while GFI1B expression is restricted to T lymphopoiesis stages coincident with activation. Transgenic expression of GFI1 potentiates T-cell activation, while forced GFI1B expression decreases activation. Both mice and humans with mutant Gfi1 display lymphoid abnormalities… CONTINUE READING