Targeted therapy: resistance and re-sensitization.

  title={Targeted therapy: resistance and re-sensitization.},
  author={Dao-Hong Chen and Xiao-shi Zhang},
  journal={Chinese journal of cancer},
  volume={34 11},
The last two decades have witnessed a paradigm shift from cytotoxic drugs to targeted therapy in medical oncology and pharmaceutical innovation. Inspired by breakthroughs in molecular and cellular biology, a number of novel synthesized chemical compounds and recombinant antibodies have been developed to selectively target oncogenic signaling pathways in a broad array of tumor types. Although targeted therapeutic agents show impressive clinical efficacy and minimized adverse effects compared… CONTINUE READING