Targeted therapies in myeloid leukemia.

  title={Targeted therapies in myeloid leukemia.},
  author={Alison M John and Nicholas S. B. Thomas and Ghulam J. Mufti and Rose Ann Padua},
  journal={Seminars in cancer biology},
  volume={14 1},
Targeted therapies for hematological malignancies have come of age since the advent of all trans retinoic acid (ATRA) for treating APL and STI571/Imatinib Mesylate/Gleevec for CML. There are good molecular targets for other malignancies and several new drugs are in clinical trials. In this review, we will concentrate on individual abnormalities that exist… CONTINUE READING