Targeted therapies in bone sarcomas.

  title={Targeted therapies in bone sarcomas.},
  author={Katia Scotlandi and Piero Picci and Heinrich Kovar},
  journal={Current cancer drug targets},
  volume={9 7},
The treatment of sarcoma urgently requires new, innovative therapeutic strategies. The most recent improvements in the cure of patients with localized disease have been achieved by dose-intensification, in turn paying the price of acute severe toxicity and secondary malignancies. Keeping side-effects to a minimum is an important goal for pediatric patients and this may be achieved by combining standard cytotoxic chemotherapy with targeted approaches. In addition, after first-line therapy, very… CONTINUE READING
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