Targeted therapies for hepatocellular carcinoma.

  title={Targeted therapies for hepatocellular carcinoma.},
  author={Augusto Villanueva and Josep M Llovet},
  volume={140 5},
Unlike most solid tumors, the incidence and mortality of hepatocellular carcinoma (HCC) have increased in the United States and Europe in the past decade. Most patients are diagnosed at advanced stages, so there is an urgent need for new systemic therapies. Sorafenib, a tyrosine kinase inhibitor (TKI), has shown clinical efficacy in patients with HCC. Studies in patients with lung, breast, or colorectal cancers have indicated that the genetic heterogeneity of cancer cells within a tumor affect… CONTINUE READING


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