Targeted sonocatalytic cancer cell injury using avidin-conjugated titanium dioxide nanoparticles.

  title={Targeted sonocatalytic cancer cell injury using avidin-conjugated titanium dioxide nanoparticles.},
  author={Kazuaki Ninomiya and Aya Fukuda and Chiaki Ogino and Nobuaki Shimizu},
  journal={Ultrasonics sonochemistry},
  volume={21 5},
In this study, we applied sonodynamic therapy to cancer cells based on the delivery of titanium dioxide (TiO2) nanoparticles (NPs) modified with avidin protein, which preferentially discriminated cancerous cells from healthy cells. Subsequently, hydroxyl radicals were generated from the TiO2 NPs after activation by external ultrasound irradiation (TiO2/US treatment). Although 30% of the normal breast cells (human mammary epithelial cells) exhibited the uptake of avidin-modified TiO2 NPs, over… CONTINUE READING


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Shun-ichi Kuroda

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