Targeted si-RNA with liposomes and exosomes (extracellular vesicles): How to unlock the potential.

@article{Antimisiaris2017TargetedSW,
  title={Targeted si-RNA with liposomes and exosomes (extracellular vesicles): How to unlock the potential.},
  author={Sophia G. Antimisiaris and Spyridon Mourtas and Konstantina Papadia},
  journal={International journal of pharmaceutics},
  year={2017},
  volume={525 2},
  pages={293-312}
}
The concept of RNA interference therapeutics has been initiated 18 years ago, and the main bottleneck for translation of the technology into therapeutic products remains the delivery of functional RNA molecules into the cell cytoplasm. In the present review article after an introduction about the theoretical basis of RNAi therapy and the main challenges encountered for its realization, an overview of the different types of delivery systems or carriers, used as potential systems to overcome RNAi… CONTINUE READING

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