Targeted ribose methylation of RNA in vivo directed by tailored antisense RNA guides

@article{Cavaille1996TargetedRM,
  title={Targeted ribose methylation of RNA in vivo directed by tailored antisense RNA guides},
  author={J. Cavaille and M. Nicoloso and Jean-Pierre Bachellerie},
  journal={Nature},
  year={1996},
  volume={383},
  pages={732-735}
}
EUKARYOTIC ribosomal RNAs are post-transcriptionally modified by methylation at the ribose sugar of specific nucleotides1. This takes place in the nucleolus and involves a family of small nucleolar RNAs (snoRNAs) with long regions (10–21 nucleotides) complementary to rRNA sequences spanning the methylation site2–4—a complementary snoRNA is required for methylation at a specific site5. Here we show that altering the sequence of the snoRNA is sufficient to change the specificity of methylation… Expand
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