Targeted retroviral gene delivery using ultrasound.

  title={Targeted retroviral gene delivery using ultrasound.},
  author={Sarah L Taylor and Ahad A Rahim and N. L. Bush and Jeffrey Bamber and C. D. Porter},
  journal={The journal of gene medicine},
  volume={9 2},
BACKGROUND Achieving specificity of delivery represents a major problem limiting the clinical application of retroviral vectors for gene therapy, whilst lack of efficiency and longevity of gene expression limit non-viral techniques. Ultrasound and microbubble contrast agents can be used to effect plasmid DNA delivery. We therefore sought to evaluate the potential for ultrasound/microbubble-mediated retroviral gene delivery. METHODS An envelope-deficient retroviral vector, inherently incapable… CONTINUE READING

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