Targeted retrieval of gene expression measurements using regulatory models

@article{Georgii2012TargetedRO,
  title={Targeted retrieval of gene expression measurements using regulatory models},
  author={Elisabeth Georgii and Jarkko Saloj{\"a}rvi and Mikael Brosch{\'e} and Jaakko Kangasj{\"a}rvi and Samuel Kaski},
  journal={Bioinformatics},
  year={2012},
  volume={28 18},
  pages={2349-56}
}
MOTIVATION Large public repositories of gene expression measurements offer the opportunity to position a new experiment into the context of earlier studies. While previous methods rely on experimental annotation or global similarity of expression profiles across genes or gene sets, we compare experiments by measuring similarity based on an unsupervised, data-driven regulatory model around pre-specified genes of interest. Our experiment retrieval approach is novel in two conceptual respects: (i… CONTINUE READING