Targeted replacement of normal and mutant CFTR sequences in human airway epithelial cells using DNA fragments.

@article{Goncz1998TargetedRO,
  title={Targeted replacement of normal and mutant CFTR sequences in human airway epithelial cells using DNA fragments.},
  author={Kaarin K. Goncz and Karl Kunzelmann and Zhengkai Xu and Dieter C. Gruenert},
  journal={Human molecular genetics},
  year={1998},
  volume={7 12},
  pages={1913-9}
}
Recent studies have reported that mutant genomic cystic fibrosis (CF) transmembrane conductance regulator ( CFTR ) sequences can be corrected in transformed CF airway epithelial cell lines by targeted replacement with small fragments of DNA with wild-type sequence. To determine if the observed genotype modification following small fragment homologous replacement (SFHR) was limited to transformed CF cell lines, further studies were carried out in both transformed and non-transformed primary… CONTINUE READING
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