Targeted reinnervation for enhanced prosthetic arm function in a woman with a proximal amputation: a case study

  title={Targeted reinnervation for enhanced prosthetic arm function in a woman with a proximal amputation: a case study},
  author={Todd A. Kuiken and Laura A. Miller and Robert D. Lipschutz and Blair A. Lock and Kathy A Stubblefield and Paul D. Marasco and Ping Zhou and Gregory A Dumanian},
  journal={The Lancet},

A Novel Targeted Sensory Reinnervation Method to Enhance Feedback and Improve Function of Myoelectric Prostheses after Upper Limb Amputation

This study investigates the feasibility of a new surgical procedure for transhumeral amputees that would allow the regenerating sensory nerve fibres from the median and ulnar nerves to reach the target sensory receptors some distance away from the reinnervated muscle in a shorter amount of time.

Novel Targeted Sensory Reinnervation Technique to Restore Functional Hand Sensation After Transhumeral Amputation

This proof of principle study is the first to demonstrate the ability to have simultaneous dual flow of information (motor and sensory) within the residual limb.

Cutaneous sensory outcomes from three transhumeral targeted reinnervation cases

These findings confirm that it is feasible to restore hand sensation after transhumeral targeted reinnervation, but there is a significant intersubject variability.

Targeted muscle reinnervation for real-time myoelectric control of multifunction artificial arms.

The results suggest that reinnervated muscles can produce sufficient EMG information for real-time control of advanced artificial arms, as well as improving the function of prosthetic arms.

Prosthesis hand grasp control following targeted muscle reinnervation in individuals with transradial amputation

Users gained some significant functional control benefits using a multi-articulating hand prosthesis with pattern recognition at 9-12 months post-TMR surgery, and a majority of subjects noted an improvement in their residual limb and phantom limb sensations post- TMR.

Targeted Reinnervation for Transhumeral Amputees: Current Surgical Technique and Update on Results

Targeted reinnervation for transhumeral amputees can now be performed in patients with amputations at the level of the middle of the humerus or longer, as described previously.

Targeted Muscle Reinnervation: A Novel Approach to Postamputation Neuroma Pain

None of the 26 patients who underwent TMR demonstrated evidence of new neuromaPain after the procedure, and all but one of the 15 patients who presented with preoperative neuroma pain experienced complete relief of pain in the distribution of the transferred nerves.

Targeted muscle reinnervation in the initial management of traumatic upper extremity amputation injury

The first report of TMR performed at the time of a traumatic shoulder disarticulation is presented, where the patient demonstrates minimal pain interference or pain behavior and exhibits no evidence of neuroma pain on clinical exam.

Targeted muscle reinnervation for the management of pain in the setting of major limb amputation

Targeted muscle reinnervation has been shown to reduce phantom limb and neuroma pain for patients with upper and lower extremity amputations and is emerging as a leading surgical technique for pain prevention in patients undergoing major limb amputations.



The use of targeted muscle reinnervation for improved myoelectric prosthesis control in a bilateral shoulder disarticulation amputee

A novel method for the control of a myoelectric upper limb prosthesis was achieved in a patient with bilateral amputations at the shoulder disarticulation level using the targeted muscle reinnervation.

Improved Myoelectric Prosthesis Control Accomplished Using Multiple Nerve Transfers

Nerve transfers to small muscle segments are capable of creating a novel neural interface for improved control of a myoelectric prosthesis in a patient with bilateral humeral disarticulations after an electrical injury.

Direct neural sensory feedback and control of a prosthetic arm

  • G. DhillonK. Horch
  • Biology
    IEEE Transactions on Neural Systems and Rehabilitation Engineering
  • 2005
This approach allows amputees to both judge and set grip force and joint position in an artificial arm, in the absence of visual input, thus providing a substrate for better integration of the artificial limb into the amputee's body image.

Neuronal ensemble control of prosthetic devices by a human with tetraplegia

Initial results for a tetraplegic human using a pilot NMP suggest that NMPs based upon intracortical neuronal ensemble spiking activity could provide a valuable new neurotechnology to restore independence for humans with paralysis.

Implantable electrical and mechanical interfaces with nerve and muscle

A review is given of various new techniques that may be clinically applicable and the issues of surgical constraints, quality of signal isolation, and long-term reliability of implantable devices, which ultimately determine the usefulness of each method are discussed.

Long-term stimulation and recording with a penetrating microelectrode array in cat sciatic nerve

It was shown that surgical technique highly affected the long-term stimulation results, and in the best case, the stimulation properties stabilized in 80% of the electrodes over the course of the experiment (162 days).