Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1.

@article{RezaiZadeh2003TargetedRO,
  title={Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1.},
  author={Natalie Rezai-Zadeh and Xiaohong Zhang and Far{\`e}s Namour and Gyorgy Fejer and Y Wen and Y C Yao and Ildik{\'o} Győry and Kenneth L. Wright and Edward Seto},
  journal={Genes & development},
  year={2003},
  volume={17 8},
  pages={1019-29}
}
Methylation of specific residues within the N-terminal histone tails plays a critical role in regulating eukaryotic gene expression. Although great advances have been made toward identifying histone methyltransferases (HMTs) and elucidating the consequences of histone methylation, little is known about the recruitment of HMTs to regulatory regions of chromatin. Here we report that the sequence-specific DNA-binding transcription factor Yin Yang 1 (YY1) binds to and recruits the histone H4 (Arg 3… CONTINUE READING