Targeted proteomics reveals compositional dynamics of 60S pre-ribosomes after nuclear export

  title={Targeted proteomics reveals compositional dynamics of 60S pre-ribosomes after nuclear export},
  author={Martin Altvater and Yiming Chang and Andre Melnik and Laura Occhipinti and Sabina Sch{\"u}tz and Ute Rothenbusch and Paola Picotti and Vikram Govind Panse},
  booktitle={Molecular systems biology},
Construction and intracellular targeting of eukaryotic pre-ribosomal particles involve a multitude of diverse transiently associating trans-acting assembly factors, energy-consuming enzymes, and transport factors. The ability to rapidly and reliably measure co-enrichment of multiple factors with maturing pre-ribosomal particles presents a major biochemical bottleneck towards revealing their function and the precise contribution of >50 energy-consuming steps that drive ribosome assembly. Here… CONTINUE READING
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