Targeted proteomics in urinary extracellular vesicles identifies biomarkers for diagnosis and prognosis of prostate cancer

@inproceedings{Sequeiros2017TargetedPI,
  title={Targeted proteomics in urinary extracellular vesicles identifies biomarkers for diagnosis and prognosis of prostate cancer},
  author={Tamara Sequeiros and Marina Rigau and Cristina Chiva and Melania Montes and Iolanda Garcia-Grau and Marta Portela Garcia and Sherley D{\'i}az and Ana Celma and Irene V Bijnsdorp and Alex D Campos and Primiano Pio Di Mauro and Salvador Borr{\'o}s and Jaume Revent{\'o}s and Andreas Doll and Rosanna Paciucci and Michiel D. Pegtel and Ines Maria de Torres and Eduard Sabid{\'o} and J M S{\'a}nchez Morote and Mireia R. Olivan},
  booktitle={Oncotarget},
  year={2017}
}
Rapid and reliable diagnosis of prostate cancer (PCa) is highly desirable as current used methods lack specificity. In addition, identification of PCa biomarkers that can classify patients into high- and low-risk groups for disease progression at early stage will improve treatment decision-making. Here, we describe a set of protein-combination panels in urinary extracellular vesicles (EVs), defined by targeted proteomics and immunoblotting techniques that improve early non-invasive detection… CONTINUE READING
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