Targeted proteomics by selected reaction monitoring mass spectrometry: applications to systems biology and biomarker discovery.

@article{Elschenbroich2011TargetedPB,
  title={Targeted proteomics by selected reaction monitoring mass spectrometry: applications to systems biology and biomarker discovery.},
  author={Sarah Elschenbroich and Thomas Kislinger},
  journal={Molecular bioSystems},
  year={2011},
  volume={7 2},
  pages={292-303}
}
Mass Spectrometry-based proteomics is now considered a relatively established strategy for protein analysis, ranging from global expression profiling to the identification of protein complexes and specific post-translational modifications. Recently, Selected Reaction Monitoring Mass Spectrometry (SRM-MS) has become increasingly popular in proteome research for the targeted quantification of proteins and post-translational modifications. Using triple quadrupole instrumentation (QqQ), specific… CONTINUE READING
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