Targeted proteomics analysis of protein degradation in plant signaling on an LTQ-Orbitrap mass spectrometer.

@article{Majovsky2014TargetedPA,
  title={Targeted proteomics analysis of protein degradation in plant signaling on an LTQ-Orbitrap mass spectrometer.},
  author={Petra Majovsky and Christin Naumann and Chil-Woo Lee and Ines Lassowskat and Marco Trujillo and Nico Dissmeyer and Wolfgang Hoehenwarter},
  journal={Journal of proteome research},
  year={2014},
  volume={13 10},
  pages={4246-58}
}
Targeted proteomics has become increasingly popular recently because of its ability to precisely quantify selected proteins in complex cellular backgrounds. Here, we demonstrated the utility of an LTQ-Orbitrap Velos Pro mass spectrometer in targeted parallel reaction monitoring (PRM) despite its unconventional dual ion trap configuration. We evaluated absolute specificity (>99%) and sensitivity (100 amol on column in 1 μg of total cellular extract) using full and mass range scans as survey… CONTINUE READING
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