Targeted proteomic dissection of Toxoplasma cytoskeleton sub-compartments using MORN1.

  title={Targeted proteomic dissection of Toxoplasma cytoskeleton sub-compartments using MORN1.},
  author={Alexander Lorestani and F Douglas Ivey and Sivasakthivel Thirugnanam and Michele A. Busby and Gabor T. Marth and Iain M Cheeseman and Marc-Jan Gubbels},
  volume={69 12},
The basal complex in Toxoplasma functions as the contractile ring in the cell division process. Basal complex contraction tapers the daughter cytoskeleton toward the basal end and is required for daughter segregation. We have previously shown that the protein MORN1 is essential for basal complex assembly and likely acts as a scaffolding protein. To further our understanding of the basal complex, we combined subcellular fractionation with an affinity purification of the MORN1 complex and… CONTINUE READING
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