Targeted prodrug design to optimize drug delivery

  title={Targeted prodrug design to optimize drug delivery},
  author={Hyo-Kyung Han and Gordon L Amidon},
  journal={AAPS PharmSci},
Classical prodrug design often represents a nonspecific chemical approach to mask undesirable drug properties such as limited bioavailability, lack of site specificity, and chemical instability. On the other hand, targeted prodrug design represents a new strategy for directed and efficient drug delivery. Particularly, targeting the prodrugs to a specific enzyme or a specific membrane transporter, or both, has potential as a selective drug delivery system in cancer chemotherapy or as an… CONTINUE READING
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