Targeted pituitary tumorigenesis using the human thyrotropin beta-subunit chain promoter in transgenic mice.

@article{Maki1994TargetedPT,
  title={Targeted pituitary tumorigenesis using the human thyrotropin beta-subunit chain promoter in transgenic mice.},
  author={Kazuhiro Maki and Ichiro Miyoshi and Yasuhiro Kon and Tetsuro Yamashita and Nobuo Sasaki and Sho Aoyama and Eri Takahashi and Shintaro Namioka and Yoshihide Hayashizaki and Noriyuki Kasai},
  journal={Molecular and cellular endocrinology},
  year={1994},
  volume={105 2},
  pages={
          147-54
        }
}
We have generated transgenic mice that express the simian virus 40 (SV40) large T antigen under the control of a 1109 bp 5'-flanking sequence of the human thyrotropin beta-subunit (TSH beta) gene. The hybrid gene, termed TTP-1, was microinjected into fertilized mouse eggs and 11 transgenic mice were obtained. One of the transgenic mice, a female, a phenotypical dwarf, developed a pituitary tumor and wasted away from 7 to 9 weeks after birth. To establish the transgenic mouse line, her ovaries… CONTINUE READING