Targeted pancreatic cancer therapy with the small molecule drug conjugate SW IV-134.

  title={Targeted pancreatic cancer therapy with the small molecule drug conjugate SW IV-134.},
  author={Yassar M. Hashim and Dirk Spitzer and Suwanna Vangveravong and M Christine Hornick and Gunjal Garg and John R. Hornick and Peter S. Goedegebuure and Robert H. Mach and W. G. Hawkins},
  journal={Molecular oncology},
  volume={8 5},
Pancreatic adenocarcinoma is highly resistant to conventional therapeutics and has been shown to evade apoptosis by deregulation of the X-linked and cellular inhibitors of apoptosis proteins (XIAP and cIAP). Second mitochondria-derived activator of caspases (Smac) induces and amplifies cell death by reversing the anti-apoptotic activity of IAPs. Thus, Smac-derived peptide analogues (peptidomimetics) have been developed and shown to represent promising cancer therapeutics. Sigma-2 receptors are… CONTINUE READING


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