Targeted overexpression of the sarcoplasmic reticulum Ca2+-ATPase increases cardiac contractility in transgenic mouse hearts.

@article{Baker1998TargetedOO,
  title={Targeted overexpression of the sarcoplasmic reticulum Ca2+-ATPase increases cardiac contractility in transgenic mouse hearts.},
  author={Debra L. Baker and Katsuji Hashimoto and Ingrid L. Grupp and Youxin Ji and Trevor Reed and Evgeny Loukianov and G. Grupp and A Bhagwhat and Brian D. Hoit and R Walsh and Eduardo Marb{\'a}n and Muthu Periasamy},
  journal={Circulation research},
  year={1998},
  volume={83 12},
  pages={
          1205-14
        }
}
Cardiac hypertrophy and heart failure are known to be associated with a reduction in Ca2+-ATPase pump levels of the sarcoplasmic reticulum (SR). To determine whether, and to what extent, alterations in Ca2+ pump numbers can affect contraction and relaxation parameters of the heart, we have overexpressed the cardiac SR Ca2+-ATPase specifically in the mouse heart using the alpha-myosin heavy chain promoter. Analysis of 2 independent transgenic lines demonstrated that sarco(endo)plasmic reticulum… CONTINUE READING

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