Targeted overexpression of insulin-like growth factor I to osteoblasts of transgenic mice: increased trabecular bone volume without increased osteoblast proliferation.

@article{Zhao2000TargetedOO,
  title={Targeted overexpression of insulin-like growth factor I to osteoblasts of transgenic mice: increased trabecular bone volume without increased osteoblast proliferation.},
  author={Guohua Zhao and Marie-Claude Monier-Faugere and M Chris Langub and Zhaopo Geng and Toshinori Nakayama and John Wesley Pike and Steven D. Chernausek and Clifford J. Rosen and Leah Rea Donahue and Hartmut H. Malluche and James A. Fagin and Thomas L. Clemens},
  journal={Endocrinology},
  year={2000},
  volume={141 7},
  pages={2674-82}
}
Insulin-like growth factor I (IGF-I) is an important growth factor for bone, yet the mechanisms that mediate its anabolic activity in the skeleton are poorly understood. To examine the effects of locally produced IGF-I in bone in vivo, we targeted expression IGF-I to osteoblasts of transgenic mice using a human osteocalcin promoter. The IGF-I transgene was expressed in bone osteoblasts in OC-IGF-I transgenic mice at high levels in the absence of any change in serum IGF-I levels, or of total… CONTINUE READING